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Chen, Hong-Chen
  • Professor
  • Education: PhD, Pathology, Cornell University, NY, USA
  • Office:  R608, 6FTradition Medicine Building
  • Phone: 886-2-28267200 (Dean Office) ; 886-2-28267123 (Office) ; 886-2-28267000#5653 (Lab)
  • Email:
1.Role of Focal Adhesion Kinase (FAK) in Tumor Invasion.
2.Role of Protein Kinase C-delta in Cell Migration and Cell-cell Junctions.
3.Interaction between Oncogenes Ras and Src

Yang, C.-Y., Chang, P.-W., Hsu, W.-H., Chang, H.-C., Chen, C.-L., Lai , C.-C., Chiu, W.-T.,and Chen, H.-C.* (2019) . Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration. Oncogene


Kuo, S.-L., Chen, C.-L., Pan, Y.-R., Chiu, W.-T., and Chen, H.-C.* (2018). Biogenesis of podosome rosettes through fission. Scientific Reports 8: 524.


Hsu, W., Wang, W., Lin, W., Huang, Y., Lai, C., Liao, J., and Chen, H.-C.* (2018). Adducin‐1 is essential for spindle pole integrity through its interaction with TPX2. EMBO Reports 19(8), e45607.


Liu, C.-M., Hsu, W.-H., Lin, W.-Y., and Chen, H.-C.* (2017). Adducin family proteins possess different nuclear export potentials. Journal of Biomedical Science 24: 30.


Chen CH, Chang WH, Su KY, Ku WH, Chang GC, Hong QS, Hsiao YJ, Chen HC, Chen HY, Wu R, Yang PC, Chen JJ, Yu SL.* (2016). HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms. Oncogene 35:5674-5685.


Chen, C.-L., Wang, S.-H., Chan, P.-C., and Chen, H.-C.* (2016). Phosphorylation of E-cadherin at threonine 790 by protein kinase Cd suppresses the function of E-cadherin. Oncotarget 7: 37260-37276.


Tsai, W.-C., Chen, C.-L., and Chen, H.-C.* (2015). Protein tyrosine phosphatase SHP2 promotes invadopodia formation through suppression of Rho signaling. Oncotarget 6:23845-23856.


Chang, C.-H., Chan, P.-C., Li, J.-R., Chen, C.-J., Shieh, J.-J., Fu, Y.-C., Chen, H.-C.,* and Wu, M-.J.* (2015). Gab1 is essential for membrane translocation, activity and integrity of mTORCs after EGF stimulation in urothelial cell carcinoma. Oncotarget 6:1478-1489.


 Chan, P.-C. Hsu, R. Y. C., Liu, C.-W., Lai, C.-C., and Chen, H.-C.* (2014). Adducin-1 is essential for mitotic spindle assembly through its interaction with myosin-X. Journal of Cell Biology 204:19-28. (highlighted article)


 Pan., Y.-R., Tseng, W.-S., Chang, P.-W., and Chen, H.-C.* (2013). Phosphorylation of moesin by Jun N-terminal kinase is important for podosome rosette formation in Src-transformed fibroblasts. Journal of Cell Science 126:5670-5680. (cover article)


Hsieh, Y.-T., Chou, M.–M., Chen, H.-C.,* and Tseng, J.-J.* (2013). IMP1 promotes choriocarcinoma cell migration and invasion through novel effectors RSK2 and PPME1. Gynecological Oncology131: 182-190.


Pan, Y.-R., Cho, K.-H., Lee, H.-H., Chang, Z.-F., and Chen, H.-C.* (2013). Protein tyrosine phosphatase SHP2 suppresses podosome rosette formation in Src-transformed fibroblasts. Journal of Cell Science 126:(2) 657-666.


Chan, P.-C. and Chen, H.-C.* (2012). P120RasGAP-medaited activation of c-Src is critical for oncogenic Ras to induce tumor invasion. Cancer Research 72: 2405-2415.


Pan, Y.-R., Chen, C.-L., and Chen, H.-C.* (2011). FAK is required for the assembly of podosome rosettes. Journal of Cell Biology 195: 113-129.


Chen, C.-L., Lin, Y.-P., Lai, Y.-C., and Chen, H.-C.* (2011). a-Adducin translocates to the nucleus upon loss of cell-cell adhesions. Traffic 12: 1327-1340.


Lu, Y.-C. and Chen, H.-C.* (2011). Involvement of lipid rafts in adhesion-induced activation of Met and EGFR. Journal of Biomedical Science 18:78.


Chen, T.-H., Chan, P.-C., Chen, C.-L., and Chen, H.-C.* (2011). Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition. Oncogene 30: 153-166.


Chan, P.-C., Sudhakar, J. N., Lai, C.-C., and Chen, H.-C.* (2010). Differential phosphorylation of the docking protein Gab1 by c-Src and the hepatocyte growth factor receptor regulates different aspects of cell functions. Oncogene 29: 698-710.


Chen, C.-L., Chan, P.-C., Wang, S.-H., Pan, Y.-R., and Chen, H.-C.* (2010). Elevated expression of protein kinase Cd induces cell scattering upon serum deprivation. Journal of Cell Science 123: 2901-2913. (highlighted article)


Lee, W.-C., Chen, H.-C., Wang, C.-Y., Lin, P.-Y., Ou, T.-T., Chen, C.-C., Wen, M.-C., Wang, J., and Lee, H.-J.* (2010). Cilostazol ameliorates nephropathy in type I diabetic rats involving in oxidative stress and regulation of TGFb and NFkB. Biosci. Biotechnol. Biochem. 74: 1355-1361.


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