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Tsai, Ying-Chieh
  • Professor
  • Education: PhD in Agriculture, Tokyo University
  • Office: R512, 5F, Tradition Medicine Building
  • Phone: 886-2-28267125
  • Email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Research--Studies on the biofilms, lactic acid bacteria, and herb essential oils
  • Scientific aromatherapy and functional studies of essential oils from Chinese herbs
  • Structural and functional studies of industrial enzymes (expandase, aminoacylase, saccharide oxidase)
  • Inhibitors of sialyltransferase and fucosyltransferase and their anti-cancer, anti-infection activities
  • Plant-derived lactic acid bacteria
  • Wound healing mechanism of sulbogin and other Chinese herbs
Publications (2006-2011)

Liu YW, Liao TW, Chen YH, Chiang YC, Tsai YC* Oral Administration of Heat-Inactivated Lactobacillus plantarum K37 Modulated Airway Hyperresponsiveness in Ovalbumin-Sensitized BALB/c Mice. (2014)PLoS One. 9(6):e100105


Wu CC, Lin CT, Wu CY, Peng WS, Lee MJ,Tsai YC* Inhibitory effect of Lactobacillus salivarius on Streptococcus mutans biofilm formation. Mol Oral Microbiol. 2014 Jun 24. [Epub ahead of print]


Chao SH, Huang HY, Chang CH, Yang CH, Cheng WS, Kang YH, Watanabe K, Tsai YC* (2013)Microbial Diversity Analysis of Fermented Mung Beans (Lu-Doh-Huang) by Using Pyrosequencing and Culture Methods. PLoS One. 8(5), e63816.


Huang HY*, Korivi M, Tsai CH, Yang JH, Tsai YC*. (2013) Supplementation of Lactobacillus plantarum K68 and Fruit-Vegetable Ferment along with High Fat-Fructose Diet Attenuates Metabolic Syndrome in Rats with Insulin Resistance Evid. based Complement. Alter. Med. 2013:943020.


Hsu CC, Lai WL, Chuang KC, Lee MH, Tsai YC*. (2013) The inhibitory activity of linalool against the filamentous growth and biofilm formation in Candida albicans. Med Mycol. 51(5):473-82.


Wei, C.L., Chao, S.H., Tsai, W.B., Lee, P.S., Tsau, N.H., Chen, J.S., Lai, W.L., Tu, J.C.Y., Tsai, Y.C.* (2013) Analysis of bacterial diversity during the fermentation of inyu, a high-temperature fermented soy sauce, using nested PCR-denaturing gradient gel electrophoresis and the plate count method. Food Microbiol. 33(2):252-261.


Mei, H.C.*, Liu, Y.W., Chiang, Y.C., Chao, S.H., Mei, N.W., Liu, Y.W., Tsai, Y.C.* (2013) Immunomodulatory Activity of Lactococcus lactis A17 from Taiwan Fermented Cabbage in OVA-Sensitized BALB/c Mice. Evid. based Complement. Alter. Med. 2013:287803.


Chao, S.H., Huang, H.Y., Kang, Y.H., Watanabe K.*, Tsai, Y.C.* (2013) The diversity of lactic acid bacteria in a traditional Taiwanese millet alcoholic beverage during fermentation. LWT-Food Sci. Technol. 51(1):135e142.


Chao, S.H., Kudo, Y., Tsai, Y.C*., and Watanabe, K. (2012) Lactobacillus futsaii sp. nov., isolated from fu-tsai and suan-tsai, traditional Taiwanese fermented mustard products. Int J Syst Evol Microbiol. 62(Pt 3):489-94.


Su, C.H., Chu, W.C., Lan, K.H., Li, C.P., Chao, Y., Lin, H.C., Lee, S.D., Tsai, Y.C.*, Lee, W.P.* (2012) Gemcitabine causes telomere attrition by stabilizing TRF2. Eur. J. Cancer 48(18):3465-74.


Chen, Y.Y., Lee, M.H., Hsu, C.C., Wei, C.L., Tsai, Y.C.* (2012) Methyl cinnamate inhibits adipocyte differentiation via activation of the CaMKK2-AMPK pathway in 3T3-L1 preadipocytes. J. Agri. Food Chem. 60(4):955-63.


Chen, W.C., Kuo, T.H., Tzeng, Y.S., Tsai, Y.C.* (2012) Baicalin induces apoptosis in SW620 human colorectal carcinoma cells in vitro and suppresses tumor growth in vivo. Molecules 17(4):3844-57.


Huang, H.Y.*, Korivi, M., Chaing, Y.Y., Chien, T.Y., Tsai, Y.C.* (2012) Pleurotus tuber-regium Polysaccharides Attenuate Hyperglycemia and Oxidative Stress in Experimental Diabetic Rats. Evid. based Complement. Alter. Med. 2012:856381.


Lai, W.L., Chuang, H.S., Lee, M.H., Wei, C.L., Lin, C.F., and Tsai, Y.C.* (2012) Inhibition of herpes simplex virus type 1 by thymol-related monoterpenoids. Planta Med. 78(15):1636-1638.


Liu, Y.W., Su, Y.W., Ong, W.K., Cheng, T.H.*, and Tsai YC.* (2011) Oral administration of Lactobacillus plantarum K68 ameliorates DSS-induced ulcerative colitis in BALB/c mice via the anti-inflammatory and immunomodulatory activities. Int Immunopharmacol. (in press)


Lee, M.H., Chen, Y.Y., Tsai, J.W., Wang, S.C., Watanabe, T., and Tsai, Y.C.* (2011) Inhibitory effect of beta-asarone, a component of Acorus calamus essential oil, on inhibition of adipogenesis in 3T3-L1 cells. Food Chemistry. 126:1-7.


Su, Y.W., Chiou, W.F., Chao, S.H., Lee, M.H., Chen, C.C.*, and Tsai, Y.C.* (2011) Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways. Int Immunopharmacol. 11:1166-72.


Huang, H.Y., Chieh, S.Y., Tso, T.K., Chien, T.Y., Lin, H.T., and Tsai, Y.C.* (2011) Orally administered mycelial culture of Phellinus linteus exhibits antitumor effects in hepatoma cell-bearing mice. J Ethnopharmacol. 133:460-6.


Liu, C.C.*, Liu, J.H., Wu, S.C., Yen, C.C., Chen, W.S. Chen, and Tsai, Y.C*. (2010) A novel E1B-55kD-deleted oncolytic adenovirus carrying mutant KRAS-regulated hdm2 transgene exerts specific antitumor efficacy on colorectal cancer cells. Mol Cancer Ther. 9:450-60.


Chen, W.C., Tzeng, Y.S., Li, H., Tien, W.S., and Tsai, Y.C.* (2010) Lung defects in neonatal and adult stromal-derived factor-1 conditional knockout mice. Cell Tissue Res. 342:75-85.


Su, Y.W., Chao, S.H., Lee, M.H., Ou, T.Y., and Tsai, Y.C.* (2010) Inhibitory effects of citronellol and geraniol on nitric oxide and prostaglandin E2 production in macrophages. Planta Med. 76:1666-1671.


Chao, S.H., Sasamoto, M., Kudo, Y., Fujimoto, J., Tsai, Y.C*., and Watanabe, K.* (2010) Lactobacillus odoratitofui sp nov, isolated from stinky tofu brine. Int. J. Syst. Evol. Microbiol. 60:2903-7. (NSC95-2313-B-010-001-MY3)


Lee, W.L., Liu, W.M., Fuh, J.L., Tsai, Y.C*., Shih, C.C., and Wang, P.H.* (2010) Basal FSH level changes after different types of uterine vessel occlusion in the management of uterine fibroids. Fertil Steril. 94:2286-90.


Lee, W.L., Liu, W.M., Fuh, J.L. Tsai, Y.C*., Shih, C.C., and Wang, P.H.* (2010) Use of uterine vessel occlusion in the management of uterine myomas: two different approaches. Fertil Steril. 94:1875-81.


Chao, S.H., Wu, R.J., Watanabe, K., and Tsai, Y.C.* (2009) Diversity of lactic acid bacteria in suan-tsai and fu-tsai, traditional fermented mustard products of Taiwan. Int. J. Food Microbiol. 135:203-210 (NSC95-2313-B-010-001-MY3)


Chao, S.H., Tomii, Y., Sasamoto, M., Fujimoto, J., Tsai, Y.C*., and Watanabe, K.* (2008) Lactobacillus capillatus sp. nov., a motile bacterium isolated from stinky tofu brine. Int. J. Syst. Evol. Microbiol. 58:2555-2559.


Chao, S.H., Tomii, Y., Watanabe, K.*, and Tsai, Y.C.* (2008) Diversity of lactic acid bacteria in fermented brines used to make stinky tofu. Int. J. Food Microbiol. 123:134-141.


Wang, P.H.,* Lee, W.L., Yang, Y.H., Chen, Y.J., Tsai, Y.C*. and Yuan, C.C. (2007) Alpha 2,6-sialyltransferase I expression in the placenta of patients with preeclampsia. J. Chin. Med. Assoc. 70:152-8.


Tsai, Y.C.,* Hsu, H.C., Yang, W.C., Tsai, W.J., Chen, C.C., and Watanabe, T. (2007) α-Bulnesene, a PAF inhibitor isolated from the essential oil of Pogostemon cablin. Fitoterapia 78:7-11.


Wang, J.P., Yeh, C.M.,* and Tsai, Y.C*. (2006) Improved subtilisin YaB production in Bacillus subtilis using engineered synthetic expression control sequences. J. Agric. Food Chem. 54:9405-9410.


Hsu, H.C., Yang, W.C., Tsai W.J., Chen, C.C., Huang, H.Y.*, and Tsai, Y.C.* (2006) α-Bulnesene, a novel PAF receptor antagonist isolated from Pogostemon cablin. Biochem. Biophys. Res. Commun. 345:1033-38.


Lee, M.H., Lai, W.L., Lin, S.F., Liu, Y., Hsu, Y.H. and Tsai, Y.C.* (2006) Purification and characterization of a novel cellooligosaccharide oxidase from rice pathogen Sarocladium oryzae. Enzyme Microbiol. Tech. 39:85-91.


Chang, W.W., Yu, C.Y., Lin, T.W., Wang P.H.*, Tsai, Y.C.* (2006) Soyasaponin I decreases the expression of α2,3-linked sialic acid on the cell surface and suppresses the metastatic potential of B16F10 melanoma cells. Biochem. Biophys. Res. Commun. 341: 614-619.


Chao, S.H., Cheng, T.H., Shaw, C.Y., Lee, M.H., Hsu, Y.H., and Tsai, Y.C.* (2006) Characterization of a novel PepF-like oligopeptidase that is secreted from Bacillus amyloliquefaciens 23-7A. Appl. Environ. Microbiol. 72:968-971.


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