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Lee, Wu Yan-Hwa
  • Education: PhD. Biochemistry, University of Tennessee
  • Office: R508, 5F, Tradition Medicine Building
  • Phone: 886-2-28267124
  • This e-mail address is being protected from spambots. You need JavaScript enabled to view it
  • Personal Web Site
  • Research--Molecular mechanism of hepatitis C and D viruses pathogenesis
  • Virus often targets critical regulatory events in host cells.  The effects of viruses on the host cells can be mediated by addition or substitution of virus-specific macromolecules to a cellular complex. Alternatively, the virus may cause a disassembly or rearrangement of a host-cell complex, or lead to the assembly of a new infected cell-specific complex. Thus, knowledge of the processes subverted by viruses has often highlighted the mechanisms of viral pathogenesis. The main goal of our study is to elaborate the types of interactions between hepatitis virus-encoded macromolecules and the host cells, which may define the ultimate outcome of a virus infection.
  • Publications
    • Chen, C.M., You, L.R., Hwang, L.H., and Lee, Y.H.W. (1997). Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-b receptor modulates the signal pathway of the lymphotoxin-b receptor. J. Virology 71, 9417-9426.

    • Yeh, T.S., and Lee, Y.H.W. (1998). Assembly of hepatitis delta virus particles: package of multimeric HDV genomic RNA and role of phosphorylation. Virology 249, 12-20.

    • You, L.R., Chen, C.M., and Lee, Y.H.W. (1999). The hepatitis C virus core protein modulates the NF-kB signal pathway triggering by lymphotoxin-b receptor ligands and tumor necrosis factor-a.  J. Virology 73, 1672-1681.

    • You, L.R., Chen, C.M., Yeh, T.S., Tsai, T.Y., Mai, R.T., Lin, C.H., and Lee, Y.H.W. (1999). Hepatitis C virus core protein interacts with cellular putative RNA helicase. J. Virology 73, 2841-2853.

    • Chung, Y.L., Lee, Y.H.W., Yen, S.H., and Chi, K.W. (2000). A novel approach for nasopharyngeal carcinoma treatment uses phenylbutyrate as a protein kinase c modulator: implications for radiosensitization and EBV-targeted theraphy. Clin. Cancer Res. 6, 1452-1458.

    • Huang, W.H. Yung, B.Y.M., Syu, W.J., and Lee, Y.H.W. (2001). The nucleolar phosphoprotein B23 interacts with hepatitis delta antigen and modulates the hepatitis delta virus RNA replication. J. Biol. Chem. 276, 25166-25175.

    • Chen, S.Y., Kao, C.F., Chen, C.M., Shih, C.M., Hsu, M.J., Chao, C.H. C., Wang, S.H., You, L.R., and Lee, Y.H.W. (2003). Mechanisms for inhibition of hepatitis B virus gene expression and replication by hepatitis C virus core protein. J. Biol. Chem. 278, 591-607.

    • Kao, C.F., Chen, S.Y., Chen, J.Y., Lee, Y.H.W. (2004) Modulation of p53 transcription regulatory activity and posttranslational modification by hepatitis C virus core protein. Oncogene 23, 2472-2483

    • Kao, C.F., Chen, S.Y., Lee, Y.H.W. (2004) Activation of RNA polymerase I transcription by hepatitis C virus core protein. J. Biomed. Sci.11, 72-94.

    • Cheng, P.L., Chang, M.H., Chao, C.H., Lee, Y.H.W. (2004) Hepatitis C viral proteins interact with Smad3 and differentially regulate the TGF-b/Smad3-mediated transcriptional activation. Oncogene 23, 7821-7838.

    • Mai, R.T., Yeh, T.S., Huang, H.H., Sun, S.K. and Lee, Y.H.W. (2006) Hepatitis C virus core protein recruits nucleolar phosphoprotein B23 and coactivator p300 to relieve the repression effect of transcription factor YY1 on B23 gene expression. Oncogene 25, 448-462.

    • Chang, P.C., Chi, C.W., Chau, G.Y., Li, F.Y., Tsai, Y.H., Wu, J.C., and Lee, Y.H.W. (2006) DDX3. a DEAD box RNA helicase, is deregulated in hepatitis virus associated hepatocellular carcinoma and is involved in cell growth control. Oncogene 25, 1991-2003.

    • Chao, C.H., Chen, C.M., Cheng, P.L., Shih, J.W., Tsou, A.P., and Lee, Y.H.W. (2006) DDX3, A DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor. Cancer Research 66(13):6579-6588

    • Lin, Y.C., Lee, Y.H.W., and J.-J. Lin (2007) Genetic analysis reveals essential and non-essential amino acids within the telomeric DNA binding interface of cdc13p. Biochem. J. 403, 289-295.

    • Liao, W.R., Hsieh, R.H. Hsu, K.W. Wu, M.Z. Tseng, M.J. Mai, R.T. Lee, Y.H.W., T.-S. Yeh. (2007) The CBF1-independent Notch signaling activates human c-myc expression partially via transcription factor YY1. Carcinogenesis 28, 1867-1876.

    • Shih, J.W., Tsai, T.Y.,Chao, C.H., and Lee, Y.H.W. (2008) Candidate tumor suppressor DDX3 RNA helicase  specifically represses cap-dependent translation by acting as an eIF4E inhibitory protein. Oncogene 27,700-714.

    • Huang, W.-H., R.-T. Mai, and Y.-H. W. Lee. (2008) Transcription factor YY1 and its associated acetyl-transferases CBP and p300 interact with hepatitis delta antigens and modulates the hepatitis delta virus RNA replication. J.Virology 82, 7313-7324.

    • Hsu, K.-W., R.-H. Hsieh, Y.-H. W. Lee, C.-H. Chao, K.-J. Wu, M.-J. Tseng, T.-S. Yeh. (2008) The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity. Mol. Cell. Biol. 28, 4829-4842.

    • Lai, M.-C., Y.-H. W. Lee, W.-Y. Tarn. (2008) The DEAD-Box RNA Helicase DDX3 Associates with Export Messenger Ribonucleoproteins as well asTip-associated Protein and Participates in Translational Control. Mol. Biol. Cell. 19, 3847-3858.

    • Liao, Y.-J., S.-P. Liu, C.-M. Lee, C.-H. Yen, P.-C. Chuang, C.-Y. Chen, T.-F. Tsai, S.-F. Huang, Y.-H. W. Lee, Y.-M. Chen. (2009) Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma. Int. J. Cancer. 124, 816-826.

    • Hsu, K.-W., R.-H. Hsieh, C.-W. Wu, C.-W. Chi, Y.-H. W. Lee, M.-L. Kuo, K.-J. Wu, T.-S Yeh. (2009) MBP-1 suppresses growth and metastasis of gastric cancer cells through COX-2. Mol. Biol. Cell 20, 5127-5137.

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